r/pharms • • Feb 14 '14

Announcement Welcome!

15 Upvotes

Since /r/pharmacuticals is dead I feel we need to bring something back.

I started this one day ago and we're already at 80+ members! Wow!

So i've been working my ass off trying to figure some CSS out and another one of the mods has been helping me (thank you /u/EvilFuckingSociopath) and I believe /u/adminsblo will be helping soon as well. However, if any of you guys know CSS we could sure use the help.

/u/kitsune-san has offered to start dropping some of his expertise on us too!

Last but not least, /u/Scienceandcheeseburg has done our entire wiki so far single handedly. Thanks man :)

So, things are a bit buggy around here for the moment. Hopefully within a few days we'll have that sorted. In the mean time, if you notice a bug please report it.

This sub wasn't made to be a sub with control freak mods so please feel free to not be too scared to post. Just don't harass each other is all I ask.

Finally, remember guys we have an IRC so stop by http://webchat.snoonet.org/#pharms


r/pharms • • Nov 29 '20

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14 Upvotes

r/pharms • • Aug 14 '14

I take a couple uppers, I down a couple downers...

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13 Upvotes

r/pharms • • Apr 01 '21

Buprenorphine completely stopped nocturnal bruxism

12 Upvotes

Hello! This is my first ever reddit post, so bear with me... I'm just looking for some help answering a question.

I am a 26 year old male. I have had extreme nocturnal jaw clenching troubles since I was very young, leading to me being prescribed opioids for severe pain that has been beyond debilitating. Chewed through every $1000 mouthguard. Over the years, no matter what medication any doctor or specialist prescribed (muscle relaxants, antidepressants, benzodiazepines, on and on), nothing could get me to stop clenching my jaw at night.

I decided to get off the opioids and switch to suboxone.

Night 1: My jaw was hanging open the entire night, to the point I had terrible dry mouth in the morning. I have never felt so well slept. My head wasn't swimming and pounding for the first time in years. My girlfriend said she had absolutely never seen me sleep that way.

No other opioid, or any other medication for that matter, has had this effect on me. I even got down to around 0.1mg of buprenorphine at night, and still, my mouth hangs open. I want to get off of suboxone, as it makes me feel pretty depressed, but every time I do the jaw clenching comes back in full force. I know it is not the naloxone that stops my jaw clenching, as my doctor has switched me purely to buprenorphine.

Has anybody here heard absolutely anything like this before? I cannot find any writing on it anywhere on the internet. Is there any medication in the world that shares a similar pharmacology to buprenorphine, without the opioid effects?

Thank you for reading, and thank you for trying to help me. I sometimes feel completely out of options, but maybe someone here will know something I don't! Hope you are well.


r/pharms • • Jun 02 '20

Why are different types of salts used in certain enantiomeric mixtures? For example: Adderall

12 Upvotes

Hi. I am curious as to why in the common pharmaceutical drug Adderall, or "Amphetamine Salts" as is listed as the RX name, there are two different types of salts used for each enantiomer:

Dextroamphetamine Saccharate
Amphetamine Aspartate Monohydrate
Dextroamphetamine Sulfate, USP
Amphetamine Sulfate, USP

These are all present in equal concentrations, so each salt makes up 1/4 of the total pill. Why don't they just use the two sulfates, or any other pairing of salts instead of having the variety?

Thanks so much


r/pharms • • Feb 18 '14

Thousands of benzos I've ordered, eaten and forgotten over the last couple of years (diaz, etiz, clonaz, alpraz) [pillpr0n]

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12 Upvotes

r/pharms • • Apr 10 '14

Adderall, Xanax, Klonopin [X-Post from /r/DrugStashes]

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11 Upvotes

r/pharms • • Feb 27 '14

Before you ask a question about Adderall XR (ER) read this.

11 Upvotes

I've seen a lot of posts about how to abuse adderall. If it's IR, just take it, snort it, plug it, shoot it.

Now, XR is a different story. Half of the medication is instant release, while the remaining half is extended release. It is bound to a polymer that takes time to break down. Abuse is still pretty easy. Use a mortar and pestle to break crush the beads into a fine powder. Personally, I use a shotglass and a drumstick. You can also use a screwdriver handle, etc. Get creative!

So, once you have your powder, you can do several things.

  1. Snort. Pretty self-explanatory. Just rail that shit hard. In my expiernce, it burns less than the orange IR addys.

  2. Repack. You repack the powder into the capsule for an instant release oral type deal. When I do this, I do not use the original capsule, as it is too small (the beads fill the whole thing, and when it's in two halves its hard to fill). I use a large gel cap, and pack it in. I bought like 200 empty gel caps online for nothing.

  3. Shoot. Make sure you use a 0.4um wheel filter, it has some nasty fillers.

  4. Smoke. You can smoke adderall XR. Use a lightbulb vaporizer. A "meth pipe" will just cause it to pool and burn. Place WHOLE beads in the bottom and smoke away. The smoke tastes like ass though.

  5. Plug. The beads can be easily crushed with a pen or the plunger-end of a syringe in a shotglass, stirred in ~3ml water, and drawn up with said syringe for administration. Both oral syringes and the needly kind are available at a pharmacy near you. Most efficient route after shooting, considering that smoking will burn/destroy some of the material, and very fast onset. Credit to /u/centrum for the plugging entry!

Have fun and be safe!


r/pharms • • Feb 26 '14

Social They're just 10/325's, but they're mine. :)

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11 Upvotes

r/pharms • • Nov 08 '19

My little box of goodies 😁

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10 Upvotes

r/pharms • • Feb 23 '14

Social Hydropornphone

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10 Upvotes

r/pharms • • Feb 16 '14

A motto to live by

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10 Upvotes

r/pharms • • Nov 02 '19

When your online friend sends you their leftovers ❤

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9 Upvotes

r/pharms • • Oct 28 '19

Pharma grade sandoz GGs. Switching to the use bars next refill. New to reddit, happy to be a member.

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9 Upvotes

r/pharms • • Apr 03 '14

$1,000-a-day miracle drug shocks U.S. health care system

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9 Upvotes

r/pharms • • Feb 20 '14

The Ativan Experience - early advertising

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9 Upvotes

r/pharms • • Dec 15 '20

Toxicology Podcast!

8 Upvotes

Hi all!

I’m a pharmacist by background from UCSF with a major fascination with all things toxicology. I cohost a podcast called That Shit is Poison! Which is a true crime toxicology podcast where the drug/toxin is the main suspect.

We’re two best friends that tell each other infamous tales of poison in history and dive deep into the pharmacology! We do a range of topics from elemental radium poisoning to LSD in MK Ultra.

We also do listener feedback, so if you have any of your own Poison stories or toxicology stories we read them on the air if you email [email protected] or DM us on Instagram @thatshitispoison

**we just did a two part series on MK Ultra, diving deep into the history and pharmacology of LSD. Part II comes out tomorrow!

https://podcasts.apple.com/us/podcast/that-shit-is-poison/id1537442195

Cheers!


r/pharms • • Jul 10 '18

Breakfast, 150 mg of dextroamphetamine. Have a lighting fast day y'all

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8 Upvotes

r/pharms • • Sep 15 '17

Baught a house and found this in the basement. What is it?

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8 Upvotes

r/pharms • • Feb 28 '16

Adolf Hitler's personal "quack" doctors records of medications and obscure pharmaceuticals used on Hitler. Toxic? Very interesting list

8 Upvotes

I can't find any facts that Vitamultin-forte actually contained methamphetamine , although some sources claim it did without evidence.

However Hitler was blindly injected with 2 other toxic stimulants (nothing good) and strychnine, which during that time was commonly used as a recreational stimulant.

Below is the most compressive list directly compiled of Hitler's doctors meticulous daily records. It's no wonder Hitler got sicker and sicker after analysis of wacky medical practices. Enjoy.

Appendix ii: The Medicines preparations administered by morell to hitler during the years –

The manufacturer is identified where known in brackets.

Hamma was the company wholly owned by Dr. Morell, with plants in Hamburg and Olmütz.

*Acidol-Pepsin (Bayer) Indicated for dyspepsia, lack of appetite.

*Antiphlogistine-Poultices (Lyssia) A paste to be applied by poultice in cases of inflammation of the joints and glands, pleurisy, bruises, knocks and abrasions.

*Belladonna Obstinol (Dr. Thiemann & Co.) Against constipation in patients with hyper- sensitive intestinal tracts. For use with patients with vegetative regulatory disorders and tendency to spasms.

*Benerva-fortissime (Roche) Indicated: Vitamin B deficiency, neuralgia, sciatica, circu- latory disorders with vitamin deficiencies; if repeatedly used in some cases it may result in shock, so it must be very slowly in- jected.

*Betabion-forte (Merck, Darmstadt) Aneurin chloride hydrochloride. Indicated: vegetative disorders.

*Bismogenol (Tosse) Bismuth campho-carbonate, used in treating the neck glands. Boxberger pills against constipation.

*Brom-Nervacit (A. Herbert Pharmacy, Wiesbaden) When Hitler became excited or aggravated, which was often, Morell would prescribe one or two tablespoons of Brom-Nervacit, an old and well-known tranquilliser consisting of  percent potassium bromide, . percent sodium phosphate, one percent naphrodyl, diethyl-Barbiturate acid, phenyldimethylpyrazolon, alcohol, sweetener and aromatics. To prevent a bromine reaction Morell would however prescribe it only during alternate eight-week periods.

*Calcium Sandoz (Sandoz, Nuremberg) Calcium gluconal actobional. Indicated: disorders of calcium metabolism. Allergic disorders. Hæmorrhages.

*Calomel Subchloride of mercury (HgCl). “Used frequently for cleansing enemas, which Hitler administered [to] himself,” says OI/CIR/;and see the diary, September , . Once a very popular medication, it was already outmoded in the s and is now obsolete.

*Cantan One tablet contained . pure l-ascorbic acid. Indicated: vitaminC deficiency.

*Cardiazol (Knoll, Ludwigshafen) In , Morell began administering Cardiazol (chemical designation: pentamethylenetetrazol) to overcome the circulatory disorder evident from the œdema observed by Morell on the external and internal malleoli (bony prominences) of Hitler’s fibulae and tibia. Normal dosage would be twenty drops taken three or four times a day. Professor Schenck says, “We now know that the effect is relatively short-lived. The drug is still available, but it is not as highly rated as it used to be.”

*Castor oil Oleum ricini. A purgative.

*Chineurin (Hamma, Olmütz) Prepared in capsules by Dr. Kurt Mulli. It contained some quinine, and was occasionally used therapeutically against colds, administered orally to Hitler after a meal, in placeof Ultraseptyl (q.v.)

*Coramin (Ciba) Well known respiratory and circulatory stimulant: Pyridin-B-carbonic acid diethylamide, used like Cardiazol.

*Cortiron (Schering) Chemical name: desoxycoticosteron acetate. Morell injected this intramuscularly into Hitler on a few occasions, to combat muscle weakness and influence the carbohydrate metabolism and fat resorption.

*Dolantin (Hoechst) Controlled by the Narcotics Act. A powerful and effective analgesic and pain-killer.

*Enterofagos ampoules (Antipiol) Indicated: Acute and chronic diseases of the gastro-in-testinal tract, constipation caused by bacteria.

*Eubasin A sulpha drug used only once by Morell, since injected intragluteally it caused pain. He used it therapeutically to cure a cold.

*Euflat This was a combined preparation of radix angelica, papaverin, aloe, active bile extracts, coffee, charcoal, pancreas extract. Morell supplied Euflat pills to Hitler to improve his digestion and combat the meteorism.

*Eukodal (Merck, Darmstadt) Dihydro hydroxycodeinon hydrochloride. Indicated: For use instead of morphine in cases of severe pain and tenderness. Familiar since , a synthetic morphium derivate, controlled by the Narcotics Act. Injected intravenously against epigastric cramps.

*Eupaverin (Merck) Synthetic alkaloid, an anti-convulsant made from poppies. Indicated: Spasms, embolisms, peripheral blood disorders. Used similarly to Eukodal. Morell would mix . gram Eukodal with . gram Eupaverin and inject them as a cocktail intravenously

*Franzbranntwein An ancient and popular liniment: alcohol, pine needle oil. Still available.

*Gallestol

*Glucose Morell injected  percent glucose, usually in cc shots, in Hitler from  to the end, to supply calories. He told his American interrogators that he injected it only every second or third day, but the diaries show he used it much more frequently. He wrote on December , : “By injecting glucose, I’m doing what I can to strengthen his heart and also to dehydrate the system.”

*Glyconorm (Nordmark Works, Hamburg) Containing metabolic ferments like Cozymase I and II, vitamins B, B and C, and the amino acids cystein, histidine, tryptophane, and a cocktail of extracts of the cardiac muscle, suprarenal gland, liver and pancreas. Used mainly to prevent pellagra, a nutritional skin disorder, and against vitamin C deficiency, carbohydrate metabolism disorders, intoxication and neuritis. Morell administered cc shots intramuscularly to check Hitler’s digestive disturbances.

*Glycovarin glucose

*Harmin An alkaloid, one of the family of drugs extracted from deadly night- shade (Solanaceæ), used against tremors, but which according to Professor Schenck has no real advantage over other such atropine-based drugs.

*Homburg 68o (Homburg) A stabilised extract from the Bulgarian belladonna (deadly nightshade) root. Indicated: all diseases of the Parkin- sonism variety, in particular that known as morbus Parkinson (paralysis agitans).

*Homoseran (Hamma, Olmütz) A preparation made from placenta, injected by Morell into Hitler for the first time on November , .

*Intelan (Ankermann & Co., Friesoythe) Tablets of this contained vitamins A and D and glucose. A typical dragée contained , international units of vitamin A, , of vitamin D-cholesterin, and  milligrams of vitamin B-Cyano complex. From  to Morell administered it like his Vitamultin to induce appetite, to combat Hitler’s lack of vitality and ability to concentrate and to increase his resistance to infection.

*Karlsbader Mühlbrunnen A mineral water.

*Karlsbader Sprudelsalz A gaseous mineral water.

*Koagovit A hæmostatic. Dr. Koester’s Anti-Gas Pills These little black spheres contained extra. Nux vom., extr. Bellad.,aa o., extr. Gent. .o. Hitler imbibed two to four pills at every meal from  to  to combat his intestinal gas build-up (meteorism). Professor Schenck states: “As Morell’s papers show, this was a completely harmless medicine.”

*Leo-Pillen (Leo Works) Laxative.

*Lugol’s Solution A compound solution of potassium iodide and iodine used for swabbing the tonsils.

*Luizym (Luitpold Works, Munich) A digestive enzyme preparation containing ferments which split cellulose, hemicellulose and carbohydrates. Indicated: to combat digestive weakness, meteorism, dyspepsia, and the Roemheld syndrome (gaseous build-up in the upper intestine causing painful pressure on the heart); and to render vegetable diets more digestible. Luizym was taken in tablet or dragée form after meals when flatulence was suffered. Still commercially available.

*Luminal (Bayer-Merck) A sedative. Phenyl-ethyl-barbiturate. Indicated: Severe insomnia, spastic and nervous conditions.

*Mitilax (Diwag Chemical Factory) Laxative. Morell wrote in one letter, “It consists of virtually pure paraffin.” Its ingredients were liquid paraffin with vanilla or coffee flavouring.

*Mutaflor (Hageda of Berlin) This emulsion of a particular strain of Bacillus coli communis was used to colonise Hitler’s intestinal tract. On the first day one yellow capsule was taken, followed by a red capsule on the second, third and fourth days and two red capsules a day after that.

*Nateina (Llopis of Madrid) A mysterious hæmostatic used on Hitler’s middle ear after the Bomb Plot of July . Nateina aroused interest in the medical world in  when it was claimed to have been successfully used on the “bleeders” of the hæmophilic Spanish royal family. In Germany it was marketed by Hageda of Berlin, a company close to Morell’s business empire.

*Neo-Pyocyanase (Südmedica) Indicated: inflammation of the upper respiratory tract; acute and chronic tonsillitis.

*Obstinol (Dr. Thiemann & Co.) Indicated: Acute and chronic constipation.

*Omnadin (I.G. Farben) Omnadin was a mixture of proteins, lipoid substances of gall and animalic fats, claimed to have antigenic properties and therefore best used at the beginning of infections. It was nearly specific against colds, and Morell preferred to use it (in intramuscular shots of one cc ampoule at a time) instead of Ultraseptyl, as it was non toxic.

*Optalidon (Sandoz, Nuremberg) Painkiller and analgesic. Morell gave Hitlerone or two tablets of this for headaches. It was a proprietary combination of amidopyrine and barbiturate, containing .Sandoptal (a proprietary hypnotic, iso-butylallyl barbituric acid);. dimethylamine phenazon (Pyramidon); and . caffeine.

*Orchikrin (Hamma, Olmütz) A combination of all the hormones of males.Potency was increased by the addition of extracts of testis, seminal vesicles and of young bulls. Orchikrin was used in pill form (one pill being equivalent to three grams of fresh testis) and also injected intramuscularly in ampoules of .cc. Morell’s chemist, Dr. Mulli, claimed it had been developed to combat cancer of the prostate. Morell suggested to American interrogators that he had tried it on Hitler only once or twice to combat fatigue or depression.

*Penicillin-Hamma (Hamma, Olmütz) Morell used this on Hitler on the evening of July, , applying it as a powder to a skin wound on his right hand.

*Phanodorm (Bayer-Merck) Cyclobarbitol, a sedative. Indicated: Insomnia or poor sleep quality.

*Profundol (Promonto) A barbiturate sleeping tablet.

*Progynon B Oleosum forte (Schering) Progynon was an esther of benzoic acid and the dihydrofollicle hormone. One ampoule was injected intramuscularly, increasing the circulation of the gastric muscles and preventing spasm of the gastric wall and vessels.

*Prostakrinum (Hamma, Olmütz) A hormone product extract of seminal vesicles and prostata. Manufactured in pill, dragées and ampoules. One pill was the equivalent of one gram of prostata and seminal vesicles. According to a letter from Hamma to Morell, on June ,, the pills had a o. gram coating of sugar. For a short periodin  Morell administered it to Hitler (two ampoules intramuscularly every second day) to ward off his depressive moods.

*Prostrophanta (Probably made by Hamma, but unlisted in any codex.) Each ampoule of Prostrophanta contained . milligrams of Strophantin (q.v.) in combination with glucose and vitamin B complex (nicotinic acid)

*Quadronox-Tabletten (Axta) Sedative.

*Relaxol (Fischer) Indicated: for various kinds of constipation.

*Sangostop A hæmostatic.

*S. E. E. injections (Merck) Later known as Scophedal, and controlled by the Narcotics Act. Indicated: pain killer, tranquilliser.

*Septoiod (Diewag Chemical Factory, Berlin) Prescribed against Hitler’s respiratory infections. A solution of three percent iodine, made up of various iodine salts. The intention was that after instillation, the free iodine would be released and disinfect inflamed areas and increase bodily resistance. Morell injected shots of up tocc intravenously. He also expected the Septoiod to retard the progress of Hitler’s coronary sclerosis, and he occasionally used it as a substitute for the toxic Ultraseptyl.

*Spasmopurin suppositories Used by Morell against Hitler’s epigastric spasms.

*Strophantin This crystalline glucoside was used as a powerful heart tonic after the August  electrocardiogram indicated that Hitler was suffering a progressive coronary sclerosis. For two or three weeks at a time Morell injected intravenously with Strophantin daily, and he continued this treatment on several occasions to the end of Hitler’s life. It was a powerful and direct-acting stimulant. Inorder to reduce the risk of inducing a cardiac arrest by injecting too high a concentration too fast, it was usually mixed with cc of glucose (sometimes in the form of the commercially premixed Prostrophanta), and both were injected in one syringe.

*Sympathol (Boehringer)(chemical name: Para-oxyphenylethanolmethylamine.) Used to increase the heart-minute-volume of blood. After Morell administered ten drops of Sympathol in a solution to be swallowed each day. Sympathol is only one-hundredth as effective as adrenaline.

*Tempidorm (Roland) A barbiturate suppository. Indicated: Insomnia, sleep disorders.

*Testoviron (Schering) Testosterone, the male sex hormone secreted by the testes. Indicated: anginal disorders, depressive conditions.

*Thrombovetren (Promonta) A heart tablet.

*Tibatin A sulphonamide drug.

*Tonophosphan (Bayer) Supplied in – percent ampoules or . gram tablets, Tonophosphan was the sodium salt of dimethyl-amino-methyl- phenyl-phosphinic acid. It was a recognised stimulant for unstriped muscles and was also administered to supply the body with phosphorus. Morell injected Tonophosphan subcutaneously in Hitler frequently during the latter years of the war.

*Tonsiosan (Schwabe)Trocken-Koli-Hamma (Hamma, Olmütz) A coli preparation developed by Professor Laves of the University of Graz, in capsules, and used as a substitute for Mutaflor (q.v.) as the Mutaflor supply dried up during the war.

*Tussamag (Tempelhof) Indicated: Expectoration; acute and chronic catarrhof the upper respiratory tract.

*Ultraseptyl (Chinoin, Budapest) A sulphonamide drug. Its chemical designation was -(p-aminobenzolsolfanamido)--methylthiazol. Morell would administer one or two tablets to Hitler, each containing. gram, with much fluid, like fruit juice or water, after a meal, against colds and infections.

*Vitamultin-Calcium (Hamma, Olmütz) Its ingredients varied, but in one form it contained ascorbic acid, calcium, vitamin C and vitamin B, and was filled into ampoules of cc. Each ampoule thus contained .gram vitamin C and . milligrams of B (aneurin)–minimal quantities which would not even remotely approach the daily needs of an adult male. It is interesting to note that Rudolf Franck’s pharmacological handbook lists as further ingredients nicotinamide and a minute quantity of p-amidobenzoyldiethylamino- ethanol hydrochloride (otherwise known as procain, the cocaine-like alkaloid now marketed as Novocaine).

*Vitamultin-forte (Hamma, Olmütz) Ampoules of this were first injected by Morell on March , , to combat Hitler’s general fatigue. Not listed in any pharmacological handbook, nor are the ingredients evident from Morell’s papers.

*Yatren One tablet of Yatren contained . grams of chinoiforum iodoxychinolinsulphate. Indicated: amœbic dysentery.

Numerical data ommited.


r/pharms • • Feb 17 '14

Social Introduce yourself to Pharms

8 Upvotes

This is to get sort of an idea of who's out there and what pharms they like to use themselves or even just which they find interesting. You can also add things such as which pharm you would love to try but haven't and maybe an idea for an exotic new pharm of your dreams....

This should allow us to open a great discussion and show us all where the like minded pharmers are in here. Don't be shy...


r/pharms • • Feb 16 '14

Announcement I scored /r/pharmacuticals!

8 Upvotes

Yay!

Edit:

Also we broke over 100 subscribers in under 2 days to the new sub! I'm proud as fuck!

I hope we can make this place awesome.


r/pharms • • Feb 14 '14

Stimulants!

8 Upvotes

Big Pharma must be really pushing the stimulant agenda to recoup their losses after the Feds cracked down on opiates. It seems like every other person I meet has a script for some kind of speed. I myself have a very generous script of pure D-Amph that would probably kill me if I took it as prescribed.

At the same time, it feels like stims are...not appreciated as much as other drugs, simply because they're everywhere! Looking for Oxy? Ket? No fucking way. Need some Adderall? Sure, no problem, I actually have some extras in my other jacket.

Not that I'm complaining!

Who else gets scripts, stimulant or otherwise, that they believe are over-generous or outright unnecessary? Or do you really need 60mg of Adderall a day to handle your extreme ADD?


r/pharms • • Jun 17 '21

Fake Irish yellow buses

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7 Upvotes

r/pharms • • Feb 16 '21

EXO-CD24 5 day cure for covid-19? how to invest in ?

7 Upvotes

Hi All, I see the headlines about a 5 day cure for those infected by Covid-19,

EXO-CD24, an experimental inhaled medication developed at Tel Aviv Sourasky Medical Center, cured all 30 moderate-to-severe cases in a Phase I clinical trial.

Developed over the past six months at the hospital, EXOCD24 stops the “cytokine storm” – where the immune system goes out of control and starts attacking healthy cells – that occurs in the lungs of 5-7% of Covid-19 patients.

Here are a couple of many references. Israeli hospital claims may have found cure for COVID-19 (ynetnews.com) and Has Israel just found the cure for Covid? - ISRAEL21c plenty more references on the net. I see the hospital where this was developed patents everything, but what I would like to identify is what pharmaceutical companies will likely be producing it? I also see some of that hospitals board are on the board of some small pharmaceutical companies in Israel, but are they likely to get the licenses to produce? in short - how can i invest in this?