Notes on podcast along with a link to the full YouTube video are below:

11:57 NAD+ discovered 100 years ago by Germans looking at extracts in yeasts.
12:30 NAD+ most abundant molecule in the body and activates sirtuins.
12:56 As we get older we make less NAD+ and we destroy more, leading to decline in ability to fight off aging.
14:30 NR can raise NAD+ levels in blood and is shown to be safe.
16:20 NR to NAD+.  Goes to cell, adds phospate to NMN, then NAD
17:18 A study on yeast showed a life extension of 30% on NR. Improvements in health, mitochondria, energy, lower inflammation.
18:20 No studies showing life extension in humans with NR.
18:50 Why not just b3?   Doesn’t raise NAD+ as much.  NMN is best. Closer to NAD+ is better.
20:00 10 days to reach peak NAD increase  
20:30 Few studies with positive results for NR in humans.  Mainly decreased inflammation.  Fails on blood glucose, insulin sensitivity, increase mito.  Maybe too short, or maybe not working.  Good for inflammation. NR + Ptero, improved ALS.
22:00 Why not just take NMN.  NR is cheaper to make, and that is why people started using NR at first.  He had no favorite, but found NMN just works better - observed.   NMN works better than NR.
23:00  NAD also has difficulty entering some cells. Neurons take it up.  Thats important and may explain IV NAD
24:50 Mice do live longer on NMN - 10-15%  - better than NR
27:00 NMN in humans - in his study (with MIB626) no results until 2022.
28:30 Other labs have shown that NMN protects organs - kidney and heart when they’re damaged. Many people undergoing heart surgery suffer from kidney damage.***
29:00 There are other NAD+ boosters even better than NMN. NCEs. In the next year - we’ll have human studies. New chemical entities are patent-protected pharmaceutical compounds.***
30:00 why not NAD+ directly?  Lots of NAD+ drips in fl and la.  No placebo controlled trials, but he says so much anecdotal evidence. Makes sense it works.
32:15 Started with Yeast - found NAD doesn’t work.
33:34 -    Bioavailability -    Just swallowing it is enough - raises NAD 2 x.    Sublingual may work better.  Hasn’t seen proof
37:00 - Resveratrol. Original work looking for sirt1 activators found resv was best, but quercetin and fisetin do as well
38:29 How much resveratrol to see an effect? 250mg a day. Insoluble in water. Mix with fats.
38:55 How to take resveratrol. It’s Insoluble so it needs to be mixed with food.
40:30 On Resv, Fat mice live as healthy and long as lean
44:00 Fisetin, Quercetin - activate sirtuins, and also kill senescent cells. Fisetin Extends lifespan 30%  in mice even when started late
45:30 Quercetin in human studies showed lowered inflammation and better liver health for fatty liver disease.
47:14 Rapamycin and rapalogs extend lifespan (inhibits mTOR) & autophagy.
49:20 Spermedine similar to rapa for mtor.  Extends life and health span in mice.  Human studies show greatly improved cognition
50:05 Spermidine study on mice showed they live longer through autophagy and it stabilizes changes to the epigenome.
50:35 Human studies on spermidine showed significant improvements in memory.
51:40 Metformin is AMPK Activator.
52:46 metformin works by inhibiting mTOR.
55:10 Metformin retrospective aging study. Metformin lowers risk of all aging-related diseases
59:00 Metformin shows possible muscle loss of around 5%.
1:01 Alternative to Metformin is Berberine. It has shown incredible effects in studies with 1-2g/day and It works just like metformin.*
1:00:00 His protocol. Full list and rundown of what he's taking and how much. Resveratrol, NMN, metformin, fisetin, quercetin and spermidine.

Supplements he's currently taking:

Resveratrol, 1 gram/day in morning in yogurt or olive oil
Alive by Science Lipo Resveratrol - https://alivebyscience.com/product/lipo-resveratrol-powdered-liposomal-resveratrol/

NMN, 1 gram/day in morning in yogurt or olive oil
Alive by Science Pure NMN - https://alivebyscience.com/product/pure-nmn-sublingual-powder-16-grams/

Metformin, 800mg/day at night, skips nights before he has a workout the next day
According to Sinclair, an alternative to Metformin is Berberine.
Alive by Science Lipo Berberine - https://alivebyscience.com/product/lipo-berberine-powdered-liposomal-berberine-90-capsules/

Spermadine, 1 gram/day in morning

Fisetin, 500mg/day in yogurt
Alive by Science Fisetin Lipo Gel - https://alivebyscience.com/product/lsg-fisetin-liposomal-sublingual-gel/

Quercetin, 500mg/day in yogurt
Alive by Science Lipo Quercetin - https://alivebyscience.com/product/lipo-quercetin-powdered-liposomal-quercetin-90-capsules-copy/

To view the entire video, click the link below:
https://www.youtube.com/watch?v=bRWT7hVgwuM

One of the hallmarks of aging is the accumulation of senescent or "zombie" cells. Senescent cells are cells which have reached their maximum cellular division (40 to 60 divisions, also known as the "Hayflick limit"), at which time cells normally undergo apoptosis, a type of programmed cellular death.

As we age, though these senescent cells do not always die off and instead continue to hang around, secreting toxins and influencing cells around them to become senescent (hence the nickname "zombie cells"), which cause inflammation in the body. The accumulation of inflammation leads to more rapid aging.

One of the best known senolytics (substances that can kill senescent cells) is Fisetin, a natural flavinoid. In a new study by the Mayo Clinic called "Targeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humans", they substantially increased the amount of Fisetin used to eliminate senescent cells from that used in previous studies (called the Mayo Clinic Fisetin protocol).

The new Mayo Clinic protocol for elimination of senescent cells using Fisetin was more than doubled as follows:

20 mg/kg/day (this is equivalent to around 1,800mg per day for an average 180lb person) for 3 consecutive days, resting one month, then repeating this procedure of 3 days on, one month off for 5 months total. This is a substantial increase over their previous protocol of 2 days on, one month off for only 2 months, showing Fisetin is safe and effective at even higher doses than previously known.

Link to Mayo Clinic study:https://clinicaltrials.gov/ct2/show/NCT04313634

Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study

A new NMN human trial echos the findings of Dr. David Sinclair's famous mouse studies, suggesting that NMN has similar effects on humans.

Sinclair's famous mouse study

In that study, giving mice NMN boosted their NAD+ and Sirt1 levels, rejuvenating endothelial function (the innermost lining of the blood vessel), stimulating blood vessel growth, and improving blood supply to their muscles.

What was most striking, though was that the capacity for exercise improved dramatically. The old mice treated with NMN had up to 80 percent greater exercise capacity compared with the older, untreated mice. When the older mice were biopsied afterwards, the mice were found to have the blood vessels and muscle tissues of a much younger mouse.

Six Week Human Trial

In the latest NMN human trial titled "Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study" a six-week randomized, double-blind, placebo-controlled, four-arm clinical trial including 48 young and middle-aged recreationally trained runners, the participants were randomized into four groups: the low dosage group (300 mg/day NMN), the medium dosage group (600 mg/day NMN), the high dosage group (1200 mg/day NMN), and the control group (placebo).

Study used young people and still showed improvement

Each group consisted of ten male participants and two female participants. Each training session was 40-60 min, and the runners trained 5-6 times each week. Cardiopulmonary exercise testing was performed at baseline and after the intervention, at 6 weeks, to assess the aerobic capacity of the runners.

Analysis of covariance of the change from baseline over the 6 week treatment showed that the oxygen uptake (VO2), percentages of maximum oxygen uptake (VO2max), power at first ventilatory threshold, and power at second ventilatory threshold increased to a higher degree in the medium and high dosage groups compared with the control group.

Conclusion: NMN increases the aerobic capacity of humans during exercise training, and the improvement is likely the result of enhanced O2 utilization of the skeletal muscle.

Link to study below:

https://pubmed.ncbi.nlm.nih.gov/34238308/

https://open.spotify.com/episode/55UlxYWPfV46f7puMkZPeD#_=_

David has been doing longer and longer podcast lately, like Lex Fridman and Whitney Cummings, where he shoots off in many different directions and many people may be bored, but I find it always interesting.

In this one, he made some new minor points and some pretty major news.

25:18 I take NMN. Our research shows it boosts atp and ? in mitochondria. Human studies ongoing, and it looks good.

30:00 in depth stuff about ATP importance

43:00 - NMN again. Mice run 50% farther. In late stage clinical trials.

46:12 - rogan asks compare inject NAD vs NMN. Sinclair says, assumption is they work the same way. Sinclair says his 1 year hip muscle problem disappeared 24 hours after NAD+ injection in the hip.

51:00 Joe says NAD+ injection is rough. But marijuana before and he did it in 10 minutes vs 30 minutes

53:45 Sinclair uses NMN for jet-lag. Says it is night and day difference

67:45 friend of sinclair just won a big marathon at 50 yr old. Is taking “these molecules” and just getting faster. nmn, metformin, resv. Who is it?

89:00 reset brain in mice. It appears permanent.

100:30 sinclair going to do his own youtube series somewhat like andrew huberman

107:00 Sinclair believes they will have some success resetting HUMANs in 2 years.

108:00 Absolutely believes humans will have ability to make old people young at some point in future

109:40 We are testing our NAD+ boosting drug against covid in 30 hospitals (metrobiotech). Maybe used against future virus pandemics

124:00 Sinclair says his epigenetic age is 10 years younger now than it was 10 years ago. Believes it is the combination of things he is doing, as he carefully measures change by change.

128:00 Sinclair says he has had no surgery or treatments

So I have used tru niagen NR for almost 4 years and had some pretty positive impacts, including a great reduction in joint and back pain. When Alive by Science started to suggest they would market a lipo NR product, I immediately pre-ordered some to test it and see if it was as good or better than tru niagen.

So far, a week into testing it, results are looking good. At age 70 with type 2 diabetes, heart disease, and high blood pressure, often you judge the change in a supplement, good or bad, based on the types of pains you are experiencing. With 900 mg of tru niagen, the only time I experienced joint or back pain was late at night or early morning, thus leading me to often take a single tylenol pm.

About 4 days after starting lipo NR at 600 mg a day (300 mg after breakfast, 300 mg after dinner), I realized that the late night and early morning joint pain and back pain was greatly diminished. Note, there have been no other changes to my supplement regimen, so I think I can truthfully say that the change is due to the lipo NR.

This is a significant benefit to my budget, since it will cut my NR costs from roughly 120 dollars a month to 60. With the savings I can purchase more lipo products once they become available, like lipo quercetin and lipo calcium alpha ketoglutarate.

**** Our review of this study has been revised with corrected dosage per clarification by the research authors *****

Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

This study examined  the effect on NAD+ levels from DNA damage leading to heart failure in mice, and the efficacy of Nicotinamide Riboside (NR) supplementation to restore NAD+.

They found 400 mg/kg of NR in the chow day did not increase NAD+ levels in the heart, or improve heart function.

In addition, they found that treatment with 1000 mg/kg of NR in chow had a detrimental effect on heart function, possibly due to excessive buildup of Nicotinamide (NAM) which inhibits Sirtuins.

After factoring in consumption per day, this equates to 569 mg per day dosage for a 70 kg human.

To convert mouse to humans:

A simple practice guide for dose conversion between animals and human

According to the authors:

“Treatment with a high dose of NR as a tool to increase NAD+ levels may inhibit rather than increase sirtuin activity due to accumulation of nicotinamide (NAM).

"Our findings so far suggest that increasing doses of NR could have non-beneficial effects on cardiac mitochondria."

“These data also suggest that the use of NR in rescuing these cardiac events should be reevaluated, in particular at higher dosages”

Read more here

Dr Brenner has been tweeting for months that NMN may be toxic to some cells.

We consult with PHD researchers in labs that study NAD+ who say you cannot draw such conclusions about what happens in vivo from a single cell study.

It is absurd that he says NMN may be toxic while NR is safe since he admits the only way NR has value is by conversion to NMN and then NAD. NR would obviously have the same problem.

Now he has changed his claim to say that “regular” NMN isn’t a problem, but only our Liposomal NMN and Metrobiotechs modified NMN.

So now he wants people to believe these two products are bad because they are too bioavaiable, while NR is safe because it has such poor bioavailability.

Anyways, if you are concerned that our Liposomal NMN might be too bioavailable, you can take Dr Brenners word that regular NMN is safe and stick to one of our sublingual NMN products.

Or, since he agrees Liposomal delivery is so much more efficient at delivering the molecules direct to the cell, ourLipsomal NAD+ is also a good bet.

Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52

34:20 Chaperone mediated Autophagy - kicks in after 2 day fast, which greatly increases longevity in mice

37:00 Sirtuins respond to glucose.

39:30 - believes in “pulsing” supplements, food, exercise

41:00 Huberman believes in pulsing, from rory hoffman, israeli special forces author of warrior diet - forerunner of intermittent fasting

45:00 Sinclair big on Metformin. Takes in mornings, except on exercise days. Doesn’t believe the minor effect on exercise matters - worth the tradeoff.

48:00 Huberman likes Berberine instead of metformin

49:00 Sinclair has studied Berberine in lab. Kaberlein published study showing Berberine shortened lifespan in mice

51:00 Resveratrol - Brown resv is bad. 1000 mg a day with fat. blood levels show increase 5x. Uses olive oil now, for the oleic acid to stimulate more

57:00 Sirtuins key. How to activate? Resveratrol was the first. the gas pedal. But they need NAD+. Eric Verdin showed CD38 chews up NAD. Need both Resv and NAD.

59:00 New!! Taking NMN for 2 weeks Will double NAD+ levels in humans. Not yet published. NMN vs NR - NMN has all components needed to make NAD. NR lacks the phosphate, which is a big disadvantage. HAVE compared NMN to NR in mice. NR did not work. Did not have the effect to increase running in mice.

103:00 - He KNOWS NMN increases NAD+ 2x. Brands? Look for well established company, quality control, GMP. White, crystalline, tastes like burnt popcorn?

105:00 stresses circadian rhythm - says he takes when traveling to reset to local time

107:00 Any immediate signs? increases insulin sensitivity. Says he feels it when stops taking. Athlete friends says improves performance. 50 year old winning marathons. Huberman sister says she feels it.

110:00 Doesn’t believe artificial sweeteners have significant negative impact.

113:00 Iron increases senescent cells. Healthy, fit people often have lower iron than MD’s recommend.

120:00 Sinclair says Hs-CRP key predictor for longevity. usually up with age. Must monitor.

122:00 Cholesterol and LDL. PSk9 better than statins? Believes recent research that shows dietary cholesterol has NO impact on blood cholesterol.

126:00 Huberman gets frustrated that everything we were told is upside down. 6 meals a day, avoid cholesterol, etc.

128:00 Sinclair likes plants for xenohormesis - a term HE came up with. Maybe that explains his bias

129:00 Sinclair likes quercetin

130:00 A little antioxidant is ok, but don’t overdo it on vitamin C E etc. Have largely been a failure.

135:00 What types of exercise best for activating sirtuins? Sinclair says maintaining muscle mass is key. He has rebuilt his body to 20’s.

This study found that supplying leukemia cells with NAD+ reversed the damage to DNA methylation and may have implications for using NAD+ in treating cancer

NAD Modulates DNA Methylation and Cell Differentiation

"In conclusion, this study bridges a nutritional intervention to a molecular observation: an increase of NAD levels in a cancer cell line results in local correction of DNA methylation. These data, therefore, provide a nutritional‐guided approach for the prevention and clinical management of cancers or other conditions associated with alteration of DNA methylation potentially linked to decreased NAD levels."

Dr. Sinclair has been attacked on twitter quite a bit recently.

He likely doesn't see it as an effective use of his time to bother responding to the constant sniping he gets from Dr. Brenner and others almost daily.

Just hold tight until he goes over all this in depth in his own podcast series coming soon.

Production is in full swing, separating fact from fiction on my limited scientific podcast series on health & longevity:

1. Skipping meals/fasting

2. Infrared saunas/cryotherapy

3. Hyperbaric oxygen chambers

4. Peptides

5. Senolytics

6. Metformin/rapamyin

7. NAD, NR, NMN

https://twitter.com/davidasinclair/status/1450835441779871752

People often ask if NMN could promote tumor growth or proliferation of cancer.

This study found that NMN supplementation did not have an impact on tumor growth.

In this research, mice were pretreated with NMN for two weeks, then they were subcutaneously injected with mouse lung cancer cells to form tumors.

When the tumor volume reached about 300 mm3, NMN was then intraperitoneally injected for three weeks. The tumor incidence, tumor size and volume were then measured.

According to the authors: 

“The role of NMN in tumor formation and lung cancer progression in vivo was fully investigated.”

“NMN does not affect the proliferation of tumor cells in vivo.”

Read more about this study and other research on NAD+ metabolism and cancer at alivebyscience.com

David Sinclair tweeted a link to a new study in Science Magazine showing more evidence that coronavirus accelerates aging.  The mouse study shows that fisetin, a molecule in fruits that kills off senescent cells can dramatically reduce covid symptoms and extend lifespan. He also stated that he's been taking fisetin for 2 years.

Alive by Science sells the most bioavailable form of fisetin on the market in a liposomal gel:
https://alivebyscience.com/product/lsg-fisetin-liposomal-sublingual-gel/

I have been using Renue for several months on my face, forehead and scalp.  Both the serum and the lotion get completely absorbed within minutes. I don't know much about NAD+ but I can tell you it's like pouring the fountain of youth into my tissues. 

My face is smoother or more even. Skin irritation clears up within minutes. Even better, I had skin damage from past sunburns on my forehead. Over 8 weeks using Renue, the rough skin reduced in size and then simply went away! My doctor told me 2 years ago to keep an eye on it and keep it from the sun. Now I have nothing to keep an eye on!

Even better, being 53, I have had a bald spot on my crown for 15 years. Still, I decided to try Renue for that too. I  took a before picture about 2.5 months ago. (Yes, I am serious and the pic is below) Then I took the same photo just last week. There is no question that the hairs are thicker and that some new hairs have returned. Renue restores youthful skin, repairs damage and seems to literally turn back time. These products are in a league of their own.

Chris B

Toronto, ON

We've Moved!

We are now Renue By Science. Please join our new subreddit at r/Renue.

Visit our new website at RenueByScience.com, and check out our six new products!

When will it be released?

I would buy this in a heartbeat. No questions asked.

This has been reported by Dr. Brad Stanfield on his YouTube channel (who is not a clinical researcher, but an MD), and by competing supplement manufacturers in their promotional material (obvious concern of bias), but the argument makes sense so I would like to hear AbS's response to this.

The argument goes that, while it is true that there is a diminished ability to produce glutathione endogenously as we age, not all tissues face this shortfall equally. Citing a study where brain autopsies were performed on a range of subjects, from babies to the elderly, it was noted that the glutathione levels in the brain were roughly uniform across all ages.

Now this could cause a concern when using liposomal glutathione, as this could elevate GSH levels even in the brain tissue where it is not needed. And excess GSH could cause reductive stress in the brain.

So my question is, how does Alive by Science view this concern about excess brain GSH levels from the liposomal GSH supplement?

And what have the customer/user reports about this product been so far?

(Here is the video in which Dr. Stanfield refers to the potential dangers of taking lipo GSH: https://www.youtube.com/watch?v=rdOJa5J6eoM )

Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

This study examined  the effect on NAD+ levels from DNA damage leading to heart failure in mice, and the efficacy of Nicotinamide Riboside (NR) supplementation to restore NAD+.

They found NR supplementation of 400 mg/kg a day did not increase NAD+ levels in the heart, or improve heart function.

In addition, they found that treatment with 1000 mg/kg of NR had a detrimental effect on heart function, possibly due to excessive buildup of Nicotinamide (NAM) which inhibits Sirtuins.

According to the authors:

“Treatment with a high dose of NR as a tool to increase NAD+ levels may inhibit rather than increase sirtuin activity due to accumulation of nicotinamide (NAM).

"Our findings so far suggest that increasing doses of NR could have non-beneficial effects on cardiac mitochondria."

“These data also suggest that the use of NR in rescuing these cardiac events should be reevaluated, in particular at higher dosages”

Read more here

A few months ago, I purchased 100g bag of ABS NMN powder and within a few days of taking it my blood pressure increased, I started getting headaches, brain fog and vertigo. Recently I changed to another brand and the symptoms started to dissipate immediately.

Has anyone else had a similar experience?

SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure

In this study researchers investigated how intracellular NAD+ (iNAD) levels are regulated in several different types of healthy cells exposed to extracellular NAD+ (eNAD).

They found eNAD+ more than doubled the quantity of iNAD+ in the cells through 3 preferred pathways. 

• direct import across the cell membrane of intact NAD+

• conversion of NAD+ to NMN, then imported by the NMN transporter Slc12a8

• further conversion of NMN to NR, then imported by NRK1

In effect, when given a good supply of eNAD+, cells used all pathways to take in more NAD+. 

Once iNAD+ was sufficient, pathways for importation of more NAD+ were shut down. 

The regulation of iNAD+ levels demonstrated in this research should be comforting to those worried about potential negative side effects from supplementation with NAD+ and its immediate precursors, as the cells studied here have an efficient means of limiting importation of excess NAD+ and precursors.

Since NAD+ is by far the most stable of these metabolites in the bloodstream and is able to utilize more pathways to increase intracellular NAD+, this study lends significant support to the use of NAD+ supplementation (vs NMN or NR) as a means of restoring NAD+ inside of cells.

- read more here

David Sinclair revealed that the genetic reset trials on humans will begin by 2023

​​​​​​​As modern science advances at a quick pace, several transhumanists believe that human beings will emerge as a hybrid species in the future, and it may even help the species to achieve immortality. And now, a Harvard genetics expert has astonishingly claimed that human studies on 'genetic reset' could help human beings to live forever.

Reversing the age to achieve immortality

Harvard professor of genetics David Sinclair revealed that the genetic reset trials will begin in 2023, and it could help humans to live beyond the current average lifespan.

Sinclair claimed that initial tests on mice have proved that aging can be reversed in the brain and other organs. While talking at the Lex Fridman podcast, the genetic expert claimed that these tests could even provide vision to blind mice.

"What we found is that there are embryonic genes that we can put into the adult animal to reset the age of tissues and it only takes four to eight weeks to work well. You can take a blind mouse that has lost its vision due to aging, neurons aren't working towards the brain, reset those neurons back to a younger age and now the mice can see again. What wasn't known was, can you partially take age back without creating a tumor or generating a stem cell in the eye, which would be a disaster, and the answer is yes," said Sinclair, Daily Star reports.

Sinclair also added that similar tests will be carried out in humans by 2023, and it could help to reverse the cell aging process. "I'm so optimistic that we are going into human studies in less than two years from now," added Sinclair.

For more, click the link below:
https://www.ibtimes.co.in/human-immortality-will-harvards-genetic-reset-trials-help-us-live-forever-837331?fbclid=IwAR1GSGcZF4DgXT9zG5YPT-OgWkfWiuddXsKL9thJsaR5G3zsAhP78xBngMY

Fisetin is showing promise as a new treatment to reduce the severity of all kinds of disease in elderly people. In a new trial by the Mayo Clinic and University of Minnesota, using Fisetin to kill senescent cells in older mice significantly reduced the mortality rate from COVID-19 virus.

By reducing the amount of senescent cells, it reduced inflammation and the immune system overreaction (called a "cytokine storm") to COVID-19 that often causes severe illnesses and deaths. Human trials using Fisetin are also being carried out to try to prevent severe COVID-19 illness and complications in nursing home residents, whose ages and illnesses can make vaccines less effective.

"If you've got a lot of senescent cells, what's going to happen is you're going to have an exaggerated response ... and you're going to get all of these things that happen in older people that kill them with COVID," said Dr. James Kirkland, director of Mayo's Kogod Center on Aging and a lead author of the Science study.

In one study, all the older lab mice who did not receive Fisetin died after exposure to COVID-19, while the younger ones survived. However, when the older mice received Fisetin to reduce senescent cells, more than half survived.

"Senescent cells reduce the ability of normal cells to fight off viruses," Kirkland said, and they "upregulate" the processes in which viruses bind to and enter healthy cells.

Tests of an anti-aging therapy in mice are boosting hopes at Mayo Clinic and the University of Minnesota about a potential COVID-19 treatment that could reduce deaths and hospitalizations and improve vaccine effectiveness. One of Mayo's trials has recruited 51 out of a goal of 70 patients hospitalized with COVID-19 to compare outcomes and antibody levels between those who receive fisetin and those who don't.

Kirkland and colleagues were among the first to hypothesize how infectious agents prompt senescent cells to increase harmful inflammation in the body.

"This approach is improving the resilience to pathogen exposure — one being coronaviruses like SARS-CoV-2 — in the elderly," said Paul Robbins, a co-director of the Institute on the Biology of Aging and Metabolism at the U Medical School. "This will just increase the chances of survival whether it's pneumonia or COVID-19 or COVID-24 or whatever is going to be next." This raises hopes that the use of Fisetin to kill senescent cells could be a new way to fight disease of all types in older people.

The results give the researchers confidence as they proceed with two human clinical trials in which they remove senescent cells from COVID-19 patients using high doses of the supplement fisetin. Senescent cells increase with age and chronic disease.

https://www.startribune.com/university-of-minnesota-mayo-report-covid-fighting-success-with-anti-aging-therapy/600066486/?refresh=true

Just ordered this and excited to try it out. Does anyone have any experiences with this?